Head coach: Ryan Day (3rd year)
Record: 11-2 (8-1 Big Ten)
Big Ten East Division Co-Champions
Spring Game – April 17
Ohio Stadium – Columbus, OH
Brutus 28, Buckeye 13
Redshirt freshman quarterback C.J. Stroud (No. 7) shined in the battle to replace first-round pick Justin Fields under center, throwing for 185 yards and two touchdowns to lead Team Brutus past Team Buckeye in the annual spring game. Early enrollee wide receiver Emeka Egbuka (No. 12) and defensive end Jack Sawyer (No. 33) also had stellar debuts, as Egbuka caught seven passes for 123 yards while Sawyer recorded four sacks.
at Minnesota – Sept. 2
Huntington Bank Stadium – Minneapolis, MN
#4 Buckeyes 45, Golden Gophers 31
Stroud threw four touchdown passes in his first career start to lead Ohio State to a victory in the Thursday night opener at Minnesota. Offensive lineman Thayer Munford (No. 75), meanwhile, became the first Block “O” recipient to wear a patch on his jersey to signify the honor, as NCAA rules prevent offensive lineman from wearing anything other than No. 50-79.
Oregon – Sept. 11
Ohio Stadium – Columbus, OH
#12 Ducks 35, #3 Buckeyes 28
Tulsa – Sept. 18
Ohio Stadium – Columbus, OH
#9 Buckeyes 41, Golden Hurricane 20
Akron – Sept. 25
Ohio Stadium – Columbus, OH
#10 Buckeyes 59, Zips 7
at Rutgers – Oct. 2
Ohio Stadium – Columbus, OH
#11 Buckeyes 52, Scarlet Knights 13
Maryland – Oct. 9
Ohio Stadium – Columbus, OH
#7 Buckeyes 66, Terrapins 17
at Indiana – Oct. 23
Ohio Stadium – Columbus, OH
#5 Buckeyes 54, Hoosiers 7
Penn State – Oct. 30
Ohio Stadium – Columbus, OH
#5 Buckeyes 33, #20 Nittany Lions 24
at Nebraska – Nov. 6
Ohio Stadium – Columbus, OH
#5 Buckeyes 26, Cornhuskers 17
Purdue – Nov. 13
Ohio Stadium – Columbus, OH
#4 Buckeyes 59, #19 Boilermakers 31
Michigan State – Nov. 20
Ohio Stadium – Columbus, OH
#4 Buckeyes 56, #7 Spartans 7
at Michigan – Nov. 27
Michigan Stadium – Ann Arbor, MI
#5 Wolverines 42, #2 Buckeyes 27
Rose Bowl Game presented by Capital One Venture X vs Utah – Jan. 1, 2022
Rose Bowl Stadium – Pasadena, CA
#6 Buckeyes 48, #11 Utes 45